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A double-blind, randomized phase 2 study comparing various doses (1, 5, 10, 15 mg) of once weekly tirzepatide, dulaglutide (1.5 mg) and placebo, in patients with T2DM, showed tirzepatide was superior on weight loss and glucose-lowering compared to both dulaglutide and placebo [52]

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In patients with schizophrenia who received cognitive remediation therapy (CRT), the volume of the hippocampus increased compared with patients who received treatment as usual, which the authors explained by the possible influence of BDNF, whose increase in concentration during the course of CRT was demonstrated in another study [104,105]