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This microenviroment, produced by the activation of platelets, represents an advantageous environment for EMT and EndoMT and may directly promote fibrogenesis [28] (Fig

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The enhanced state of oxidative stress, coupled with the inadequate regulatory impact of BBBs on oxidative stress, allows harmful free radicals and oxidative stress factors to penetrate the brain more easily (Plascencia-Villa and Perry, 2023)