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It is possible that multiple autoantigens are necessary to induce robust T cell proliferation as was shown in an analogous T1D study that used antigen recall assays and HLA delineation ( 5.3 GABA trial in adults with prediabetes In overweight adults with prediabetes, De Bie and colleagues examined the effect of oral GABA on glycemic control using a double-blind, randomized and placebo-controlled study design (NCT04303468) (156)