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Patients were followed for 2 years, with IGF-I levels measured at 3-month intervals with GH doses adjusted as warranted

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Oxidative Stress and Advanced Glycation End Products (AGEs) in IDD In the presence of oxidative stress, the increase of ROS led to the trigger of lipid peroxidation and glycosylation reactions, which result in the increased endogenous generation of reactive aldehydes and their by-products, including glyoxal, methylglyoxal, malondialdehyde, and 4-hydroxy-2-nonenal, leading to advanced lipid oxidation end products and advanced glycosylation end products (ALE and AGE, respectively) [55]