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In a more advanced strategy, brain-targeted nanoparticles were developed by modifying poly(ethylene glycol)-poly( ε -caprolactone) (PEG-PCL) carriers with Angiopep-2, a peptide known for its strong ability to penetrate the BBB (Rabha et al., 2021)

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Additionally, living microbial species supplemented with a diet could improve the health benefits to the hosts of aquatic organisms ( Characteristic features of probiotics Probiotics improve the host defense system and resistance to foreign substances or harmful microbes