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When treated with both the 1.44 mg/kg dose and the 2.88 mg/kg dose of Dihexa, the APP/PS1 mice experienced an increase in the number of neuronal cells present in the cerebral cortex

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We initiated our investigation with the oxidation of furan 1 using N -bromosuccinimide (NBS) in CH 3 COCH 3 :H 2 O as the solvent to generate cis −2-butene-1,4-dial (BDA) in situ followed by a sequential reaction with 1-butanethiol and 1-butylamine in one pot to generate a single N -pyrrole heterocyclic product 2a