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Compound heterozygotes can manifest later in life

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Serotonin System Extracellular levels of serotonin are moderated by the membrane protein 5-HT transporter, and with the exception of the ionotropic 5-HT 3 receptor, 5-HT exerts effects through seven families of G protein–coupled receptors (5-HT 1–7 ) with ≥14 subtypes (for a review, see Berger et al., 2009)