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In addition, IGF1 promotes cell proliferation by increasing the production of PG and promoting cell metabolism, thereby increasing the nutritional requirements of the intervertebral discs (Pratsinis and Kletsas, 2007

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Various inhibitors targeting HDAC6, including ricolinostat, tubastatin A (TubA) and ACY-1215, have been developed and are undergoing clinical trials to evaluate their effectiveness in treating cancer and neurodegenerative disorders (19-21)