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Search terms included combinations of the following Medical Subject Headings (MeSH) and keywords: “riboflavin” OR “vitamin B2” OR “flavin adenine dinucleotide” OR “flavin mononucleotide” AND “neurological disease” OR “nervous system disorder” OR “brain disease” AND “mitochondria” OR “oxidative stress” OR “inflammation” OR “gene therapy” OR “riboflavin transporter deficiency” OR disease-specific terms (e.g., “migraine,” “Parkinson’s disease,” “multiple sclerosis,” “MADD,” “BVVL”)

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These cells are chosen for their robust signaling capabilities, which are essential for achieving a significant therapeutic response in an osteoarthritic joint