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The Chemistry Behind Storage and Stability Rules Why peptides degrade in aqueous nasal spray solutions faster than lyophilized powder: Peptide bonds undergo hydrolysis in the presence of water, a reaction that is temperature-dependent and follows Arrhenius kinetics

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Such challenges have been worked on by investigators from the Alzheimer’s, Parkinson’s and prionopathy fields for decades, and we suggest that emerging methods for interrogating protein misfolding could be very applicable to research into the foundations of MS as well