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because L-cells accumulate chloride, activation of these channels exerts a depolarizing effect that promotes calcium influx and GLP-1 secretion.28 Although the impact of supplemental glycine on GLP-1 production has not been assessed in vivo, oral gelatin, notably rich in glycine, has been shown to boost GLP-1 levels.42,43 Glycine administered in a morning fasting metabolism has been shown to provoke increased glucagon secretion, likely reflecting a direct or indirect stimulatory effect on pancreatic alpha cells.44 Because both GLP-1 and glucagon boost hepatic fatty acid oxidation, these hormones might collaborate in mediating the protective impact of supplemental glycine on fructose-fed rats.41 Díaz-Flores et al administered 15-g glycine daily (5 g, 3 times daily) to patients with metabolic syndrome

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PRECAUTIONS, Pregnancy]