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It is not yet well-understood how these bacteria can exert these benefits, but documented mechanisms of action include antimicrobial activity against major gastrointestinal 171 and urogenital pathogens 172 , barrier-promoting effects at the gut epithelium 173 and other mucosa 174 , immunomodulatory effects by stimulating host antimicrobial compounds such as α- defensins 175 and modulating the secretion of cytokines such as IL-10, IL-6, IL-1b, IL-2, TNF-α, and impacting different cell types such as intestinal epithelial cells, dendritic cells, macrophages and regulatory T cells 176–178

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How Supplied Pemetrexed Injection is supplied as a sterile single-dose vial containing clear colorless to yellow or green-yellow solution in a clear glass vial with a grey rubber closure, aluminum cap, and light blue flip-off cap Storage and Handling Store solution at 25°C (77°F)